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Study identifier: NCT04434482 Synced from ClinicalTrials.gov · July 28, 2026
● Completed

IMP4297 in Combination With Temozolomide in Patients With Advanced Solid Tumors and Small Cell Lung Cancer

Condition: Advanced Solid Tumours · Small Cell Lung Cancer  ·  Sponsor: Impact Therapeutics, Inc.

PhasePhase 1/Phase 2
Planned participants59
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is an open-label, multi-center, dose-escalation and dose-expansion phase I study to evaluate the safety, tolerability, PK characteristics and anti-tumor activity of PARP inhibitor IMP4297 and temozolomide combination therapy in patients with advanced solid tumors and with ES-SCLC who develops disease progression after 1L platinum-based regimen.

This description comes directly from the study's public registry record.

Talk to the study team

Contact details are listed per location below or on the registry record.

Always discuss trial participation with your own doctor first.

Locations (21)

GenHarp Clinical SolutionsEvergreen Park, Illinois, United States
Gabrail Cancer Researh CenterCanton, Ohio, United States
Mark H. Zangmeister CenterColumbus, Ohio, United States
Sarah Cannon Research Institute - Tennessee OncologyTennessee City, Tennessee, United States
Border Medical OncologyAlbury, New South Wales, Australia
Blacktown HospitalBlacktown, New South Wales, Australia
Orange HospitalOrange, New South Wales, Australia
Peninsula Health Frankston HospitalFrankston, Victoria, Australia
Beijing Cancer HospitalBeijing, China
Jilin Cancer HospitalJilin City, China
Fudan University Shanghai Cancer CenterShanghai, China
Hubei Cancer HospitalWuhan, China

+ 9 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT04434482