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Study identifier: NCT04433572 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Temsirolimus Adventitial Delivery to Improve ANGioplasty and/or Atherectomy Revascularization Outcomes Below the Knee

Condition: Peripheral Artery Disease · Critical Limb Ischemia  ·  Sponsor: Mercator MedSystems, Inc.

PhasePhase 3
Planned participants250
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

A multicenter, randomized, double-blind, placebo-controlled trial to evaluate the effect of Temsirolimus Perivascular Injection 0.1 mg/mL on the incidence of ischemia-driven major amputation, clinically driven target lesion revascularization, and clinically relevant target lesion occlusion after revascularization of lesions below the knee in patients with symptomatic Rutherford 3-5 peripheral artery disease. The primary safety endpoint will be gathered at 1-month post-index procedure. The primary efficacy endpoint will be gathered at 6 months post-index procedure. Participants will be followed for up to 5 years post-index procedure.

This description comes directly from the study's public registry record.

Talk to the study team

Kirk Seward, PhD  ·  (510) 614-4555  ·  kseward@mercatormed.com

Always discuss trial participation with your own doctor first.

Locations (2)

Cardiovascular Institute of the SouthHouma, Louisiana, United StatesRecruiting
UT SouthwesternDallas, Texas, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT04433572