Condition: CD19 Negative B-cell Malignancies · Sponsor: Shenzhen Geno-Immune Medical Institute
This study will evaluate safety and efficacy of a combination of 4th generation chimeric antigen receptor gene-modified T cells (4SCAR-T) targeting CD19-negative B-ALL that express alternative surface antigens such as CD22, CD10, CD20, CD38, and CD123, as many patients relapse after anti-CD19 immunotherapy. Clinical response and optiminzation of a standardized lentiviral vector and cell production protocol will be investigated. This is a phase I/II trial enrolling patients from multiple clinical centers.
This description comes directly from the study's public registry record.
Lung-Ji Chang, phD · +86 0755-86573763 · c@szgimi.org
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| Shenzhen Geno-Immune Medical Institute | Shenzhen, Guangdong, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT04430530