Condition: Advanced Hepatocellular Carcinoma · Stage III Hepatocellular Carcinoma AJCC v8 · Stage IIIA Hepatocellular Carcinoma AJCC v8 · Sponsor: Mary Feng, MD
This phase II trial studies how well standard of care hypofractionated radiation therapy followed by durvalumab with or without tremelimumab works in treating patients with hepatocellular cancer (liver cancer) that has spread to other places in the body (advanced) and that is growing, spreading, or getting worse (progressing). In some patients, cancer cells and immune cells start to express signals that stop the body's immune system from killing the cancer. New drugs being developed, such as durvalumab and tremelimumab, are designed to target and block these signals and may help increase the immune response to prevent or slow down cancer growth. Hypofractionated radiation therapy delivers higher doses of radiation therapy over a shorter period of time and may help the immune system work even better. Giving durvalumab with or without tremelimumab after radiation therapy may work better than radiation therapy alone in treating patients with liver cancer.
This description comes directly from the study's public registry record.
Luchia Andemicael · (415) 530-9814 · Luchia.Andemicael@ucsf.edu
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| University of California, San Francisco | San Francisco, California, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT04430452