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Study identifier: NCT04422912 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Phase 1/2, Open-label, Safety and Dosing Study of Autologous CART Cells (Desmoglein 3 Chimeric Autoantibody Receptor T Cells [DSG3-CAART] or CD19-specific Chimeric Antigen Receptor T Cells [CABA-201]) in Subjects With Active, Pemphigus Vulgaris (RESET-PV)

Condition: Pemphigus Vulgaris  ·  Sponsor: Cabaletta Bio

PhasePhase 1/Phase 2
Planned participants40
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

A phase 1/2, open-label, safety and dosing study of autologous CART cells (desmoglein 3 chimeric autoantibody receptor T cells \[DSG3-CAART\] or CD19-specific Chimeric Antigen Receptor T cells \[CABA-201\]) in subjects with active, pemphigus vulgaris

This description comes directly from the study's public registry record.

Talk to the study team

Cabaletta Bio  ·  +1 267 759 3100  ·  clinicaltrials@cabalettabio.com

Always discuss trial participation with your own doctor first.

Locations (13)

Stanford University, Dept. of DermatologyRedwood City, California, United StatesRecruiting
UC Davis, Dept. of DermatologySacramento, California, United StatesRecruiting
Yale UniversityNew Haven, Connecticut, United StatesRecruiting
Northwestern UniversityChicago, Illinois, United StatesRecruiting
University of IowaIowa City, Iowa, United StatesRecruiting
Brigham and Women's HospitalBoston, Massachusetts, United StatesRecruiting
Mount Sinai - Icahn School of MedicineNew York, New York, United StatesWithdrawn
Columbia UniversityNew York, New York, United StatesRecruiting
University of North Carolina, Department of DermatologyChapel Hill, North Carolina, United StatesWithdrawn
University of PennsylvaniaPhiladelphia, Pennsylvania, United StatesRecruiting
UT Southwestern Medical Center, Dept. of DermatologyDallas, Texas, United StatesRecruiting
MD Anderson Texas Medical CenterHouston, Texas, United StatesRecruiting

+ 1 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT04422912