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Study identifier: NCT04421560 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Pembrolizumab, Ibrutinib and Rituximab in PCNSL

Condition: Primary Central Nervous System Lymphoma · Recurrent Cancer · Refractory Cancer  ·  Sponsor: Dana-Farber Cancer Institute

PhasePhase 1/Phase 2
Planned participants37
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This research study is evaluating a combination therapy of 3 drugs as possible treatments for recurrent primary central nervous system lymphoma (PCNSL). The three drugs being used in the study are: * Pembrolizumab (MK3475) * Ibrutinib * Rituximab (or biosimilar)

This description comes directly from the study's public registry record.

Talk to the study team

Lakshmi Nayak, MD  ·  (617) 632-2166  ·  lnayak2@partners.org

Always discuss trial participation with your own doctor first.

Locations (4)

Dana Farber Cancer InstituteBoston, Massachusetts, United StatesRecruiting
Beth Israel Deaconess Medical CenterBoston, Massachusetts, United StatesRecruiting
Columbia University Medical CenterNew York, New York, United StatesWithdrawn
Memorial Sloan Kettering Cancer CenterNew York, New York, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT04421560