← Eichor
Study identifier: NCT04410796 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Osimertinib Alone or With Chemotherapy for EGFR-Mutant Lung Cancers

Condition: Metastatic Non-small Cell Lung Cancer  ·  Sponsor: Memorial Sloan Kettering Cancer Center

PhasePhase 2
Planned participants571
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study will compare the effectiveness of osimertinib alone with the combination of osimertinib and chemotherapy (carboplatin and pemetrexed) in people with metastatic lung cancer that has a change (mutation) in the gene EGFR. Osimertinib alone is the usual treatment for metastatic EGFR-mutant lung cancer. Researchers think adding chemotherapy to osimertinib could possibly add to the anticancer effects of the usual treatment and help stop cancer from growing or spreading.

This description comes directly from the study's public registry record.

Talk to the study team

Helena Yu, MD  ·  646-608-2252  ·  yuh@mskcc.org

Gregory Riely, MD, PhD  ·  646-608-3913

Always discuss trial participation with your own doctor first.

Locations (18)

UC Davis Cancer Center (Data Collection Only)Sacramento, California, United StatesRecruiting
University of California San FranciscoSan Francisco, California, United StatesActive Not Recruiting
Moffitt Cancer CenterTampa, Florida, United StatesRecruiting
John Hopkins Medical CenterBaltimore, Maryland, United StatesRecruiting
Massachusetts General Hospital (Data Collection Only)Boston, Massachusetts, United StatesRecruiting
Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)Basking Ridge, New Jersey, United StatesRecruiting
Hackensack Meridian HealthHackensack, New Jersey, United StatesRecruiting
Memorial Sloan Kettering Monmouth (Limited Protocol Activities)Middletown, New Jersey, United StatesRecruiting
Memorial Sloan Kettering Bergen (Limited Protocol Activities)Montvale, New Jersey, United StatesRecruiting
Memorial Sloan Kettering Commack (Limited protocol activities)Commack, New York, United StatesRecruiting
Memorial Sloan Kettering Westchester (Limited protocol activities)Harrison, New York, United StatesRecruiting
New York UniversityNew York, New York, United StatesRecruiting

+ 6 more locations — full list on the registry record.

Follow this study

Get one email when the public record changes — results posted, or the study's status changes. Nothing else, ever.

We email about this public record only. Unsubscribe anytime with one click. Never medical advice.

Is this your study? This page was generated automatically from the public registry record. Sponsors can claim it — free — to add branding and verified contact routing. Claim this page →

This page is independently generated by Eichor from the public ClinicalTrials.gov record and re-synced daily. It is not the sponsor's official website unless claimed. Nothing here is medical advice; eligibility is always determined by the study team — talk to your own doctor first.

Source record: clinicaltrials.gov/study/NCT04410796