Condition: Acute Aortic Syndrome · Sponsor: Nanjing Medical University
Acute aortic syndrome (AAS) is a life-threatening condition. Inflammation plays a key role in the pathogenesis, development and progression of AAS, and is associated with significant mortality and morbidity. Understanding the inflammatory responses and inflammation resolutions is essential for an appropriate management of AAS. Twenty Chinese cardiovascular centers have collaborated to create a multicenter observational registry (named Chinese registry of Additive Anti-inflammatory Action for Aortopathy \& Arteriopathy \[5A\]), with consecutive enrollment of adult patients who underwent surgery for AAS that was started on Jan 1, 2016 and will be ended on December 31, 2040. Specially, the impact of inflammation and anti-inflammatory strategies on the early and late adverse events are investigated. Primary outcomes are severe systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), Sequential Organ Failure Assessment (SOFA) scores at 7 days following this current surgery. Secondary outcomes are SISR, 30-day mortality, operative mortality, hospital mortality, new-onset stroke, acute kidney injury, surgical site infection, reoperation for bleeding, blood transfusion and length of stay in the intensive care unit.
This description comes directly from the study's public registry record.
Hong Liu, MD · 02568303100 · DR.HONGLIU@FOXMAIL.COM
Hai-yang LI, MD · ocean0203@163.com
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| Beijing Fuwai Hospital Chinese Academy of Medical Sciences | Beijing, Beijing Municipality, China | Recruiting |
| Chongqing Hospital of Jiangsu Provincial People's Hospital | Chongqing, Chongqing Municipality, China | Recruiting |
| Guangdong Provincial People's Hospital | Guangzhou, Guangdong, China | Recruiting |
| The First Affiliated Hospital of Guangxi Medical University | Nanning, Guangxi, China | Recruiting |
| QianXiNan People's Hospital | Xingyi, Guizhou, China | Recruiting |
| The Second Affiliated Hospital of Harbin Medical University | Harbin, Heilongjiang, China | Recruiting |
| The Third Affiliated Hospital of Soochow University | Changzhou, Jiangsu, China | Recruiting |
| Suqian Hospital of of Nanjing Medical University | Suqian, Jiangsu, China | Recruiting |
| Dongtai People's Hospital | Yancheng, Jiangsu, China | Recruiting |
| Subei People's Hospital of Jiangsu Province | Yangzhou, Jiangsu, China | Recruiting |
| the Second Affiliated Hospital of Nanchang University | Nanchang, Jiangxi, China | Recruiting |
| Qilu Hospital of Shandong University | Jinan, Shandong, China | Recruiting |
+ 22 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT04398992