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Study identifier: NCT04398628 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

ATHN Transcends: A Natural History Study of Non-Neoplastic Hematologic Disorders

Condition: Hematologic Disorder · Bleeding Disorder · Connective Tissue Disorder  ·  Sponsor: American Thrombosis and Hemostasis Network

PhaseN/A
Planned participants3000
Who can joinAll sexes, N/A to no upper limit
Healthy volunteersNo

About this study

In parallel with the growth of ATHN's clinical studies, the number of new therapies for all blood disorders is increasing significantly. Some of the recently FDA-approved therapies for congenital and acquired hematologic conditions have not yet demonstrated long-term safety and effectiveness beyond the pivotal trials that led to their approval. In addition, results from well controlled, pivotal studies often cannot be replicated once a therapy has been approved for general use.2,3,4,5 In 2019 alone, the FDA has issued approvals for 24 new therapies for congenital and acquired hematologic conditions.6 In addition, almost 10,000 new studies for hematologic diseases are currently registered on www.clinicaltrials.gov.7 With this increase in potential new therapies possible, it is imperative that clinicians and clinical researchers in the field of non-neoplastic hematology have a uniform, secure, unbiased, and enduring method to collect long-term safety and efficacy data. As emphasized in a recently published review, accurate, uniform and quality national data collection is critical in clinical research, particularly for longitudinal cohort studies covering a lifetime of biologic risk.8

This description comes directly from the study's public registry record.

Talk to the study team

Carol Fedor, ND, RN, CCRC  ·  800-360-2846  ·  cfedor@athn.org

Nana Ama Afari-Dwamena, MPH  ·  800-360-2846  ·  nafaridwamena@athn.org

Always discuss trial participation with your own doctor first.

Locations (71)

Arizona Hemophilia and Thrombosis Treatment Center at Phoenix Children's HospitalPhoenix, Arizona, United StatesRecruiting
Arkansas Center for Bleeding DisordersLittle Rock, Arkansas, United StatesRecruiting
Orthopaedic Institute for Children HTCLos Angeles, California, United StatesRecruiting
Childrens Hospital Los AngelesLos Angeles, California, United StatesRecruiting
UCSF Benioff Children's Hospital OaklandOakland, California, United StatesRecruiting
University of California at Davis Hemophilia Treatment CenterSacramento, California, United StatesRecruiting
Loma Linda Hemoglobinopathy and Inherited Bleeding Disorder ProgramSan Bernardino, California, United StatesRecruiting
Hemophilia & Thrombosis Treatment Center at UC San Diego HealthSan Diego, California, United StatesRecruiting
Rady Children's Hospital San DiegoSan Diego, California, United StatesRecruiting
University of California, San Francisco Hemophilia & Thrombosis CenterSan Francisco, California, United StatesRecruiting
Connecticut Children's Medical CenterHartford, Connecticut, United StatesRecruiting
Yale Hemophilia Treatment CenterNew Haven, Connecticut, United StatesRecruiting

+ 59 more locations — full list on the registry record.

Follow this study

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Source record: clinicaltrials.gov/study/NCT04398628