Condition: Carcinoma, Non-Small Cell Lung · Squamous Cell Carcinoma of Head and Neck · HER2 Negative Breast Neoplasms · Sponsor: Seagen, a wholly owned subsidiary of Pfizer
This trial will look at a drug called sigvotatug vedotin (SGN-B6A) alone and with pembrolizumab, with or without chemotherapy, to find out whether it is safe for people who have solid tumors. It will study sigvotatug vedotin to find out what its side effects are. A side effect is anything the drug does besides treating cancer. It will also study whether sigvotatug vedotin works to treat solid tumors. The study will have four parts. * Part A of the study will find out how much sigvotatug vedotin should be given to participants. * Part B will use the dose found in Part A to find out how safe sigvotatug vedotin is and if it works to treat solid tumors. * Part C of the study will find out how safe sigvotatug vedotin is in combination with these other drugs. * Part D will include people who have not received treatment. This part of the study will find out how safe sigvotatug vedotin is in combination with these other drugs and if these combinations work to treat solid tumors. * In Parts C and D, participants will receive sigvotatug vedotin with either: * Pembrolizumab or, * Pembrolizumab and carboplatin, or * Pembrolizumab and cisplatin.
This description comes directly from the study's public registry record.
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| Alaska Oncology and Hematology | Anchorage, Alaska, United States | Recruiting |
| Highlands Oncology Group | Fayetteville, Arkansas, United States | Recruiting |
| Highlands Oncology Group | Rogers, Arkansas, United States | Recruiting |
| Highlands Oncology Group | Springdale, Arkansas, United States | Recruiting |
| Providence Medical Foundation | Anaheim, California, United States | Recruiting |
| Providence Medical Foundation | Fullerton, California, United States | Recruiting |
| Providence St. Jude Medical Center Virginia K Crosson and Infusion Center | Fullerton, California, United States | Recruiting |
| Cancer and Blood Research Center, LLC | Los Alamitos, California, United States | Not Yet Recruiting |
| Cancer and Blood Specialty Clinic | Los Alamitos, California, United States | Not Yet Recruiting |
| Ronald Reagan UCLA Medical Center | Los Angeles, California, United States | Recruiting |
| The Regents of the University of California | Los Angeles, California, United States | Recruiting |
| UCLA Department of Medicine-Hematology/Oncology | Los Angeles, California, United States | Recruiting |
+ 146 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT04389632