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Study identifier: NCT04389086 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Induction Chemotherapy for Locally Recurrent Rectal Cancer

Condition: Recurrent Rectal Cancer  ·  Sponsor: Catharina Ziekenhuis Eindhoven

PhasePhase 3
Planned participants364
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a multicentre, open-label, parallel arms, phase IIII study that randomises patients with locally recurrent rectal cancer in a 1:1 ratio to receive either induction chemotherapy followed by neoadjuvant chemoradiotherapy and surgery (experimental arm) or neoadjuvant chemoradiotherapy and surgery alone (control arm)

This description comes directly from the study's public registry record.

Talk to the study team

Stefi Nordkamp, MD  ·  0031 40 2398858  ·  stefi.nordkamp@catharinaziekenhuis.nl

Floor Piqeur, MD  ·  0031 40 2397152  ·  floor.piqeur@catharinaziekenhuis.nl

Always discuss trial participation with your own doctor first.

Locations (14)

UZ GentGhent, BelgiumNot Yet Recruiting
Amsterdam UMCAmsterdam, NetherlandsRecruiting
Antoni van LeeuwenhoekAmsterdam, NetherlandsRecruiting
Catharina HospitalEindhoven, NetherlandsRecruiting
University Medical Centre GroningenGroningen, NetherlandsRecruiting
Leids University Medical CentreLeiden, NetherlandsRecruiting
Haaglanden Medical CentreLeidschendam, NetherlandsRecruiting
Maastricht University Medical CentreMaastricht, NetherlandsRecruiting
Erasmus Medical CentreRotterdam, NetherlandsRecruiting
Oslo UniversitetssykehusOslo, NorwayNot Yet Recruiting
Instituto Portugues de Oncologia de Lisboa Francisco Gentil, E.P.E.Lisbon, PortugalNot Yet Recruiting
Sahlgrenska UniversitetssjukhusetGothenburg, SwedenNot Yet Recruiting

+ 2 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT04389086