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Study identifier: NCT04381468 Synced from ClinicalTrials.gov · July 28, 2026
● Completed

SEMA4D Blockade Safety and Brain Metabolic Activity in Alzheimer's Disease (AD)

Condition: Alzheimer Disease  ·  Sponsor: Vaccinex Inc.

PhasePhase 1/Phase 2
Planned participants50
Who can joinAll sexes, 55 Years to 85 Years
Healthy volunteersNo

About this study

To investigate safety, tolerability, the effects on cognition and brain metabolism of pepinemab in early AD dementia (early AD) subjects.

This description comes directly from the study's public registry record.

Talk to the study team

Contact details are listed per location below or on the registry record.

Always discuss trial participation with your own doctor first.

Locations (14)

Pacific Research Network, IncSan Diego, California, United States
Georgetown UniversityWashington D.C., District of Columbia, United States
Brain Matters ResearchDelray Beach, Florida, United States
Neuropsychiatric Research Center of Southwest FloridaFort Myers, Florida, United States
JEM Research InstituteLake Worth, Florida, United States
Premiere Research Institute of Palm Beach, NeurologyPalm Beach, Florida, United States
Brain Matters ResearchStuart, Florida, United States
Indiana University School of MedicineIndianapolis, Indiana, United States
University of Kansas Medical CenterFairway, Kansas, United States
Neurological Associates of AlbanyAlbany, New York, United States
Dent Neurological AssociatesAmherst, New York, United States
Columbia University Irving Medical CenterNew York, New York, United States

+ 2 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT04381468