Condition: Parkinson's Disease Psychosis · Sponsor: VA Office of Research and Development
Patients with Parkinson's disease (PD) sometimes experience symptoms affecting their movement, such as slowness, tremor, stiffness, and balance or walking problems. Many patients also have other symptoms not related to movement, called non-motor symptoms, which may affect one's mood or emotions, memory or thinking, or cause one to see or hear things that aren't real (hallucinations) or believe things that aren't true (delusions). Hallucinations or delusions, together called psychosis, occur in up to 60% of PD patients at some point in time. Parkinson's disease psychosis can sometimes be associated with decreased quality of life, increased nursing home placement, increased rate of death, and greater caregiver burden. There are approximately 50,000 Veterans with Parkinson's disease receiving care in the VA, and up to 30,000 (60%) of them will experience psychosis at some point in time. Quetiapine is an antipsychotic drug approved by the Food and Drug Administration (FDA) that is the most commonly used medication to treat PD psychosis, but more studies are needed to determine if it works for this condition and is also well tolerated and safe. Pimavanserin is a newer antipsychotic drug approved by the Food and Drug Administration (FDA) specifically to treat PD psychosis, but more studies are needed to determine if it works and its safety. The purpose of this research is to gather additional information on the safety and effectiveness of both Quetiapine and Pimavanserin. By doin…
This description comes directly from the study's public registry record.
Daniel Weintraub, MD · (215) 823-5800 · daniel.weintraub@va.gov
John E Duda, MD · (215) 823-5934 · john.duda@va.gov
Always discuss trial participation with your own doctor first.
| Southern Arizona VA Health Care System, Tucson, AZ | Tucson, Arizona, United States | Terminated |
| VA Loma Linda Healthcare System, Loma Linda, CA | Loma Linda, California, United States | Recruiting |
| VA Palo Alto Health Care System, Palo Alto, CA | Palo Alto, California, United States | Recruiting |
| San Francisco VA Medical Center, San Francisco, CA | San Francisco, California, United States | Active Not Recruiting |
| VA Greater Los Angeles Healthcare System, West Los Angeles, CA | West Los Angeles, California, United States | Terminated |
| Rocky Mountain Regional VA Medical Center, Aurora, CO | Aurora, Colorado, United States | Recruiting |
| North Florida/South Georgia Veterans Health System, Gainesville, FL | Gainesville, Florida, United States | Active Not Recruiting |
| Edward Hines Jr. VA Hospital, Hines, IL | Hines, Illinois, United States | Active Not Recruiting |
| Lexington VA Medical Center, Lexington, KY | Lexington, Kentucky, United States | Terminated |
| VA Ann Arbor Healthcare System, Ann Arbor, MI | Ann Arbor, Michigan, United States | Active Not Recruiting |
| Minneapolis VA Health Care System, Minneapolis, MN | Minneapolis, Minnesota, United States | Recruiting |
| St. Louis VA Medical Center John Cochran Division, St. Louis, MO | St Louis, Missouri, United States | Active Not Recruiting |
+ 12 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT04373317