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Study identifier: NCT04366518 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Toward a Computationally-Informed, Personalized Treatment for Hallucinations

Condition: Hallucinations, Auditory · Psychosis  ·  Sponsor: Yale University

PhaseEARLY_Phase 1
Planned participants35
Who can joinAll sexes, 18 Years to 65 Years
Healthy volunteersNo

About this study

Auditory hallucinations are among the most distressing aspects of psychotic illness, and between 10 and 30% of people with hallucinations do not respond to antipsychotic medications. The authors have used computational modeling of behavior to link brain activity to development of auditory hallucinations in the hope of guiding new treatment development. The proposed studies take the first step toward individualized treatment approaches to hallucinations by attempting causal, pharmacological manipulation of relevant model parameters underlying these phenomena.

This description comes directly from the study's public registry record.

Talk to the study team

Albert Powers, MD, PhD  ·  203-974-7329  ·  albert.powers@yale.edu

Silmilly Toribio  ·  silmilly.toribio@yale.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Connecticut Mental Health CenterNew Haven, Connecticut, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT04366518