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Study identifier: NCT04363164 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Sequential Testosterone and Enzalutamide Prevents Unfavorable Progression

Condition: Castration Resistant Metastatic Prostate Cancer  ·  Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

PhasePhase 2
Planned participants150
Who can joinMale, 18 Years to 90 Years
Healthy volunteersNo

About this study

Asymptomatic men without pain due to prostate cancer progressing with metastatic CRPC after treatment with combination or sequential ADT + Abi will be treated on a randomized, open label study to determine if sequential treatment with high dose T and Enza will improve primary and secondary objectives vs. continuous Enza as standard therapy.

This description comes directly from the study's public registry record.

Talk to the study team

GU oncology  ·  4109551239  ·  ProstateCancerClinicalTrials@live.johnshopkins.edu

Harry Cao, MA  ·  443-287-6882  ·  hcao7@jhmi.edu

Always discuss trial participation with your own doctor first.

Locations (6)

University of California, San Diego (UCSD)San Diego, California, United StatesRecruiting
Johns Hopkins University/Sidney Kimmel Cancer CenterBaltimore, Maryland, United StatesRecruiting
Dana-Faber Cancer InstituteBoston, Massachusetts, United StatesRecruiting
University of MinnesotaMinneapolis, Minnesota, United StatesRecruiting
University of Nebraska Medical CenterOmaha, Nebraska, United StatesRecruiting
University of Washington/Fred Hutchinson Cancer CenterSeattle, Washington, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT04363164