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Study identifier: NCT04356469 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

TCR Alpha Beta T-cell Depleted Haploidentical HCT in the Treatment of Non-Malignant Hematological Disorders in Children

Condition: Hemoglobinopathy (Disorder) · Severe Aplastic Anemia · Bone Marrow Failure Syndrome  ·  Sponsor: Johns Hopkins All Children's Hospital

PhasePhase 2
Planned participants17
Who can joinAll sexes, 0 Years to 21 Years
Healthy volunteersNo

About this study

This research is being done to learn if a new type of haploidentical transplantation using TCR alpha beta and CD19 depleted stem cell graft from the donor is safe and effective to treat the patient's underlying condition. This study will use stem cells obtained via peripheral blood or bone marrow from parent or other half-matched family member donor. These will be processed through a special device called CliniMACS, which is considered investigational.

This description comes directly from the study's public registry record.

Talk to the study team

Jade Hanson, MSN  ·  7277676468  ·  jade.hanson@jhmi.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Johns Hopkins All Children's HospitalSt. Petersburg, Florida, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT04356469