Condition: Lung Adenocarcinoma · Cryotherapy Effect · Sponsor: Institut Bergonié
This study aims to compare the one-year survival benefit of the association of cryoablation-pembrolizumab-pemetrexed-carboplatin versus pembrolizumab-pemetrexed-carboplatin in metastatic lung adenocarcinoma patients. This is a multicenter, prospective, open-labeled, 2-arm comparative randomized (1:1) phase III trial. Patients will be randomized with a 1:1 ratio into: * Arm A (experimental arm): cryoablation of one visceral lesion or bone metastasis excluding liver and sclerotic bone metastases combined with pembrolizumab and pemetrexed-carboplatin prescribed as per market authorization. * Arm B (standard arm): pembrolizumab and pemetrexed-carboplatin prescribed as per market authorization. Pembrolizumab and pemetrexed-carboplatin will be prescribed and administered at the dose recommended by market authorization. Cryoablation treatment should be performed within 6 weeks after the first administration of pembrolizumab. No treatment switching permitted.
This description comes directly from the study's public registry record.
Jean PALUSSIERE, MD · 05.56.33.33.47 · j.palussiere@bordeaux.unicancer.fr
Simone MATHOULIN-PELISSIER, MD, PhD · s.mathoulin@bordeaux.unicancer.fr
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| Institut Bergonié | Bordeaux, Gironde, France | Recruiting |
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Source record: clinicaltrials.gov/study/NCT04339218