← Eichor
Study identifier: NCT04333706 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Dose Finding Phase 1 of Sarilumab Plus Capecitabine in HER2/Neu-Negative Metastatic Breast Cancer and a Single-arm, Historically-controlled Phase 2 Study of Sarilumab Plus Capecitabine in Stage I-III Triple Negative Breast Cancer With High-Risk Residual Disease (EMPOWER)

Condition: Breast · Metastatic · Triple Negative  ·  Sponsor: University of Southern California

PhasePhase 1/Phase 2
Planned participants65
Who can joinAll sexes, 18 Years to 99 Years
Healthy volunteersNo

About this study

This study looks to advance a novel and potent strategy to eliminate minimal residual disease (MRD) in triple negative breast cancer (TNBC) present even after multimodal treatment, thereby improving survival and increasing cure rate in this aggressive cancer. Patients with locally advanced TNBC are at high risk of developing lethal metastatic disease within 2 years of diagnosis, especially for those without a pathologic complete response (pCR) after neoadjuvant chemotherapy. The high risk occurs despite surgical excision of the primary tumor and axillary lymph nodes to eliminate residual disease.

This description comes directly from the study's public registry record.

Talk to the study team

Kimberly Arieli, RN  ·  323-865-3935  ·  Kimberly.Arieli@med.usc.edu

Always discuss trial participation with your own doctor first.

Locations (3)

Los Angeles General Medical CenterLos Angeles, California, United StatesRecruiting
USC/Norris Comprehensive Cancer CenterLos Angeles, California, United StatesRecruiting
UF HealthGainesville, Florida, United StatesActive Not Recruiting

Follow this study

Get one email when the public record changes — results posted, or the study's status changes. Nothing else, ever.

We email about this public record only. Unsubscribe anytime with one click. Never medical advice.

Is this your study? This page was generated automatically from the public registry record. Sponsors can claim it — free — to add branding and verified contact routing. Claim this page →

This page is independently generated by Eichor from the public ClinicalTrials.gov record and re-synced daily. It is not the sponsor's official website unless claimed. Nothing here is medical advice; eligibility is always determined by the study team — talk to your own doctor first.

Source record: clinicaltrials.gov/study/NCT04333706