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Study identifier: NCT04333537 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Comparing Sentinel Lymph Node (SLN) Biopsy With Standard Neck Dissection for Patients With Early-Stage Oral Cavity Cancer

Condition: Buccal Mucosa Squamous Cell Carcinoma · Floor of Mouth Squamous Cell Carcinoma · Gingival Squamous Cell Carcinoma  ·  Sponsor: NRG Oncology

PhasePhase 2/Phase 3
Planned participants686
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This phase II/III trial studies how well sentinel lymph node biopsy works and compares sentinel lymph node biopsy surgery to standard neck dissection as part of the treatment for early-stage oral cavity cancer. Sentinel lymph node biopsy surgery is a procedure that removes a smaller number of lymph nodes from your neck because it uses an imaging agent to see which lymph nodes are most likely to have cancer. Standard neck dissection, such as elective neck dissection, removes many of the lymph nodes in your neck. Using sentinel lymph node biopsy surgery may work better in treating patients with early-stage oral cavity cancer compared to standard elective neck dissection.

This description comes directly from the study's public registry record.

Talk to the study team

Contact details are listed per location below or on the registry record.

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Locations (107)

University of Alabama at Birmingham Cancer CenterBirmingham, Alabama, United StatesWithdrawn
Banner MD Anderson Cancer CenterGilbert, Arizona, United StatesRecruiting
Mayo Clinic Hospital in ArizonaPhoenix, Arizona, United StatesRecruiting
Banner University Medical Center - TucsonTucson, Arizona, United StatesRecruiting
University of Arizona Cancer Center-North CampusTucson, Arizona, United StatesRecruiting
University of Arkansas for Medical SciencesLittle Rock, Arkansas, United StatesRecruiting
City of Hope Comprehensive Cancer CenterDuarte, California, United StatesActive Not Recruiting
UC San Diego Moores Cancer CenterLa Jolla, California, United StatesRecruiting
Stanford Cancer Institute Palo AltoPalo Alto, California, United StatesRecruiting
University of California Davis Comprehensive Cancer CenterSacramento, California, United StatesActive Not Recruiting
UC San Diego Medical Center - HillcrestSan Diego, California, United StatesRecruiting
UCSF Medical Center-Mission BaySan Francisco, California, United StatesRecruiting

+ 95 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT04333537