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Study identifier: NCT04332874 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Study of Pembrolizumab Plus Local Chemotherapy Using Isolated Limb Infusion (ILI) for Patients With Sarcoma in the Arm or Leg

Condition: Sarcoma · Myxofibrosarcoma · Undifferentiated Pleomorphic Sarcoma  ·  Sponsor: Memorial Sloan Kettering Cancer Center

PhasePhase 2
Planned participants30
Who can joinAll sexes, 12 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this study is to find out whether giving the study drug pembrolizumab in combination with the chemotherapy drugs melphalan and dactinomycin, delivered directly to the affected arm or leg using a technique called isolated limb infusion (ILI), is a safe treatment that can delay the time before your disease gets worse (progresses).

This description comes directly from the study's public registry record.

Talk to the study team

Edmund Bartlett, MD  ·  212-639-2448  ·  bartlete@mskcc.org

Charlotte Ariyan, MD, PhD  ·  212-639-6280  ·  ariyanc@mskcc.org

Always discuss trial participation with your own doctor first.

Locations (7)

Memorial Sloan Kettering Basking Ridge (Limited protocol activities)Basking Ridge, New Jersey, United StatesRecruiting
Memorial Sloan Kettering Monmouth (Limited protocol activities)Middletown, New Jersey, United StatesRecruiting
Memorial Sloan Kettering Bergen (Limited Protocol Activities)Montvale, New Jersey, United StatesRecruiting
Memorial Sloan Kettering Cancer Center @ Suffolk - Commack (Limited Protocol Activities)Commack, New York, United StatesRecruiting
Memorial Sloan Kettering Westchester (Limited Protocol Activities)Harrison, New York, United StatesRecruiting
Memorial Sloan Kettering Cancer CenterNew York, New York, United StatesRecruiting
Memorial Sloan Kettering Nassau (Limited Protocol Activities)Uniondale, New York, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT04332874