Condition: Clinical Stage IV Gastric Cancer AJCC v8 · Clinical Stage IVA Gastric Cancer AJCC v8 · Clinical Stage IVB Gastric Cancer AJCC v8 · Sponsor: City of Hope Medical Center
This phase I trial studies the side effects of pressurized intraperitoneal aerosol chemotherapy (PIPAC) in treating patients with ovarian, uterine, appendiceal, stomach (gastric), or colorectal cancer that has spread to the lining of the abdominal cavity (peritoneal carcinomatosis). Chemotherapy drugs, such as cisplatin, doxorubicin, oxaliplatin, leucovorin, fluorouracil, mitomycin, and irinotecan, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. PIPAC is a minimally invasive procedure that involves the administration of intraperitoneal chemotherapy. The study device consists of a nebulizer (a device that turns liquids into a fine mist), which is connected to a high-pressure injector, and inserted into the abdomen (part of the body that contains the digestive organs) during a laparoscopic procedure (a surgery using small incisions to introduce air and to insert a camera and other instruments in the abdominal cavity for diagnosis and/or to perform routine surgical procedures). Pressurization of the liquid chemotherapy through the study device results in aerosolization (a fine mist or spray) of the chemotherapy intra-abdominally (into the abdomen). Giving chemotherapy through PIPAC may reduce the amount of chemotherapy needed to achieve acceptable drug concentration, and therefore potentially reduces side effects and toxicities.
This description comes directly from the study's public registry record.
Contact details are listed per location below or on the registry record.
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| City of Hope Medical Center | Duarte, California, United States | Recruiting |
| Mayo Clinic in Florida | Jacksonville, Florida, United States | Active Not Recruiting |
| Northwell Health Cancer Institute at Huntington | Greenlawn, New York, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT04329494