Condition: Refractory Pain · Sponsor: Institut Cancerologie de l'Ouest
Ziconotide is a strong analgesic marketed since 2005 in Europe and reserved for the intrathecal route. Its efficacy has been proven in particular by 3 randomized clinical studies. It is particularly effective on neuropathic pain and its main advantages are its power of action, the absence of bone marrow toxicity, and the absence of respiratory depression. In addition, there were no signs of withdrawal when stopping the drug, or of tachyphylaxis. However, during these studies many adverse reactions were highlighted, especially neuropsychiatric which limited its use. This toxicity was mainly related to the administration of too high doses, especially at the start of treatment (too fast titration). In recent years, the use of intrathecal ziconotide has become a pertinent option. Indeed, it is recommended as first-line among the intrathecal treatment options. However, there is a lack of data on the current use of ziconotide in current practice. The objective of the study will be to describe the practical methods of using intrathecal treatments containing ziconotide.
This description comes directly from the study's public registry record.
DENIS DUPOIRON, MD · +33 241352700 · denis.dupoiron@ico.unicancer.fr
MARINE TIGREAT · +33 240679878 · marine.tigreat@ico.unicancer.fr
Always discuss trial participation with your own doctor first.
| Institut de Cancerologie de L'Ouest | Angers, France | Active Not Recruiting |
| Centre Hospitalier Departemental La Roche Sur Yon | La Roche-sur-Yon, France | Active Not Recruiting |
| Centre Leon Berard | Lyon, France | Active Not Recruiting |
| Institut de Cancerologie de Montpellier | Montpellier, France | Suspended |
| Clinique Breteche | Nantes, France | Suspended |
| CHU NICE | Nice, France | Suspended |
| Institut Curie | Saint-Cloud, France | Suspended |
| Hopital - Foch | Suresnes, France | Active Not Recruiting |
| University of Freiburg | Freiburg im Breisgau, Germany | Recruiting |
| Justus-Liebig-Universitat | Giessen, Germany | Recruiting |
| Jena University Hospital | Jena, Germany | Recruiting |
| Hospital Universitario Puerta Del Mar | Cadiz, Spain | Recruiting |
+ 5 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT04321408