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Study identifier: NCT04315324 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Study to Test OBI-3424 in Patients With T-Cell Acute Lymphoblastic Leukemia (T-ALL) or T-Cell Lymphoblastic Lymphoma (T-LBL)

Condition: Recurrent T Acute Lymphoblastic Leukemia · Refractory T Acute Lymphoblastic Leukemia · Refractory T Lymphoblastic Lymphoma  ·  Sponsor: SWOG Cancer Research Network

PhasePhase 1/Phase 2
Planned participants67
Who can joinAll sexes, 12 Years to no upper limit
Healthy volunteersNo

About this study

This phase I/II trial studies the safety, side effects and best dose of OBI-3424 and how well it works in treating patients with T-cell acute lymphoblastic leukemia or T-cell lymphoblastic lymphoma that has come back (relapsed) or does not respond to treatment (refractory). Chemotherapy drugs, such as OBI-3424, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. OBI-3424 may reduce the amount of leukemia in the body.

This description comes directly from the study's public registry record.

Talk to the study team

Contact details are listed per location below or on the registry record.

Always discuss trial participation with your own doctor first.

Locations (163)

University of Alabama at Birmingham Cancer CenterBirmingham, Alabama, United StatesActive Not Recruiting
Kingman Regional Medical CenterKingman, Arizona, United StatesRecruiting
Arkansas Children's HospitalLittle Rock, Arkansas, United StatesRecruiting
PCR OncologyArroyo Grande, California, United StatesRecruiting
City of Hope Comprehensive Cancer CenterDuarte, California, United StatesRecruiting
Loma Linda University Medical CenterLoma Linda, California, United StatesRecruiting
Children's Hospital of Orange CountyOrange, California, United StatesRecruiting
Children's Hospital ColoradoAurora, Colorado, United StatesRecruiting
Alfred I duPont Hospital for ChildrenWilmington, Delaware, United StatesRecruiting
Golisano Children's Hospital of Southwest FloridaFort Myers, Florida, United StatesRecruiting
Memorial Regional Hospital/Joe DiMaggio Children's HospitalHollywood, Florida, United StatesRecruiting
Johns Hopkins All Children's HospitalSt. Petersburg, Florida, United StatesRecruiting

+ 151 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT04315324