Condition: Ewing Sarcoma · Rhabdomyosarcoma · Wilms Tumor · Sponsor: New York Medical College
Investigators are testing new experimental drug combinations such as the combination of vorinostat, vincristine, irinotecan, and temozolomide in the hopes of finding a drug that may be effective against tumors that have come back or that have not responded to standard therapy. The goals of this study are: * To find the highest safe dose of vorinostat that can be given together with vincristine, irinotecan, and temozolomide without causing severe side effects; * To learn what kind of side effects this four drug combination can cause; * To learn about the effects of vorinostat and the combination of vorinostat, vincristine, irinotecan, and temozolomide on specific molecules in tumor cells; * To determine whether the combination of vorinosat, vincristine, irinotecan, and temozolomide is a beneficial treatment.
This description comes directly from the study's public registry record.
Harshini Mahanti, BS · 914-594-2143 · harshini_mahanti@nymc.edu
Lauren Harrison, MSN · 617-285-7844 · lauren_harrison@nymc.edu
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| New York Medical College | Valhalla, New York, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT04308330