Condition: Motor Neuron Disease, Amyotrophic Lateral Sclerosis · Sponsor: University of Edinburgh
MND-SMART is investigating whether selected drugs can slow down the progression of motor neuron disease (MND) and improve survival. The study is 'multi-arm' meaning more than one treatment will be tested at the same time. The trial started with 3 arms; drug 1 (memantine), drug 2 (trazodone) and placebo (dummy drug). A third drug, amantadine, was added in April 2023. A fourth drug, tacrolimus, was added in March 2025 in Edinburgh and across all sites in April 2025. The first two drugs, memantine and trazodone, were removed from the trial in September 2023 due to lack of benefit. The trial currently has 4 recruiting arms; amantadine, liquid placebo (matched to amantadine), tacrolimus, and tablet placebo (matched to tacrolimus). This allows the evaluation of each drug versus placebo. Participants will be randomly allocated between the treatment arms they are eligible for. Medicines being tested are already approved for use in other conditions. MND-SMART has an 'adaptive' design. This means medicines being studied can change according to emerging results. Treatments shown to be ineffective can be dropped and new drugs can be added over the duration of the study. This will allow many treatments, over time, to be efficiently and definitively evaluated. The medicines being tested have been selected following a rigorous process involving a systematic, unbiased, and comprehensive review of past clinical trials data, as well as information from pre-clinical research (studies in labo…
This description comes directly from the study's public registry record.
Professor Chandran · 0131 465 9612 · siddharthan.chandran@ed.ac.uk
Amy Stenson · 0131 242 9122 · astenson@exseed.ed.ac.uk
Always discuss trial participation with your own doctor first.
| Southern Health and Social Care Trust, Craigavon Area Hospital | Portadown, County Armagh, United Kingdom | Recruiting |
| Aberdeen Royal Infirmary | Aberdeen, United Kingdom | Recruiting |
| University Hospitals of Birmingham NHS Foundation Trust | Birmingham, United Kingdom | Recruiting |
| University Hospitals Sussex NHS Foundation Trust | Brighton, United Kingdom | Recruiting |
| West Suffolk NHS Foundation Trust | Bury St Edmunds, United Kingdom | Recruiting |
| Cambridge University Hospitals NHS Foundation Trust | Cambridge, United Kingdom | Recruiting |
| Cardiff and Vale University Local Health Board | Cardiff, United Kingdom | Recruiting |
| Clinical Research Centre , Ninewells Hospital | Dundee, United Kingdom | Recruiting |
| Anne Rowling Regenerative Neurology Clinic | Edinburgh, United Kingdom | Recruiting |
| Royal Devon and Exeter Hospital | Exeter, United Kingdom | Recruiting |
| Queen Elizabeth University Hospital Clinical Research Facility | Glasgow, United Kingdom | Recruiting |
| NHS Highland Clinical Research Facility, Raigmore Hospital | Inverness, United Kingdom | Recruiting |
+ 10 more locations — full list on the registry record.
Get one email when the public record changes — results posted, or the study's status changes. Nothing else, ever.
We email about this public record only. Unsubscribe anytime with one click. Never medical advice.
This page is independently generated by Eichor from the public ClinicalTrials.gov record and re-synced daily. It is not the sponsor's official website unless claimed. Nothing here is medical advice; eligibility is always determined by the study team — talk to your own doctor first.
Source record: clinicaltrials.gov/study/NCT04302870