Condition: Diffuse Large B Cell Lymphoma · Sponsor: Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS
This is a prospective and retrospective observational study. The primary objective is to identify new prognostic biomarkers for DLBCL patients in terms of progression-free survival (PFS) and able to add predictive capacity to recognized important clinical factors. The secondary objectives are: * to identify new biomarkers associated with overall survival (OS) and objective response rate (ORR) * to characterize tissue and circulating immune microenvironment of DLBCL patients by bulk and single cell transcriptomics; * to assess the correlation between the expression of immune checkpoint genes and mRNA signature; * to describe the mutational status of a panel of genes relevant to DLBCL pathogenesis;. * to assess the correlation between protein expression, mutational status and the messenger RNA (mRNA) signature. * to investigate the association between radiomic features obtained from PET images and patient and tumour characteristics and clinical outcomes (PFS, OS, ORR). For each enrolled patient, immunohistochemical determinations will be performed: Cell of origin (COO) (Germinal Cell -GC- or activated B-cell - ABC- type according with Hans algorithm ), evaluation of cluster of differentiation antigen 20 (CD20), cluster of differentiation antigen 5 (CD5), cluster of differentiation antigen 10 (CD10), Bcl6, Bcl2 (cut off\>50%), Multiple Myeloma 1 / Interferon Regulatory Factor 4 protein (MUM1/IRF4), c-myc (cut off\>40%) and Ki67, fluorescence in situ hybridization (FISH) for c…
This description comes directly from the study's public registry record.
Oriana Nanni, Dr · +39 0543739100 · oriana.nanni@irst.emr.it
Bernadette Vertogen, Dr · +39 0544285813 · cc.ubsc@irst.emr.it
Always discuss trial participation with your own doctor first.
| Irst Irccs | Meldola, FC, Italy | Recruiting |
| Ospedale S. Maria delle Croci RAVENNA | Ravenna, RA, Italy | Recruiting |
| L'Azienda Ospedaliero-Universitaria Di Bologna Policlinico S. Orsola-Malpighi | Bologna, Italy | Recruiting |
| Ospedale Infermi | Rimini, Italy | Recruiting |
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Source record: clinicaltrials.gov/study/NCT04300101