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Study identifier: NCT04298723 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Comparison of LAA-Closure vs Oral Anticoagulation in Patients With NVAF and Status Post Intracranial Bleeding.

Condition: Intracranial Hemorrhages · Atrial Fibrillation (AF) · Atrial Flutter  ·  Sponsor: Jena University Hospital

PhaseNA
Planned participants530
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Atrial fibrillation is the most common cardiac arrhythmia. In atrial fibrillation, there is a risk that clots can form in the heart, especially in the left atrium. If these clots come loose, there is a risk of stroke. To prevent strokes, patients with atrial fibrillation and status post ICB can be treated with anticoagulants. This medication therapy prevents blood clots from forming in the heart, but can also cause bleeding. Another therapy option is the occlusion of the left atrium. After closure of the left atrium, only a short anticoagulation therapy is necessary until the occluder has healed. The aim of the study is to compare these two treatment approaches. In this study only already approved drugs and occlusion systems will be used.

This description comes directly from the study's public registry record.

Talk to the study team

Sven Möbius-Winkler, Prof. Dr.  ·  +4936419324503  ·  sven.moebius-winkler@med.uni-jena.de

Marcus Winter  ·  +4936419396648  ·  marcus.winter@med.uni-jena.de

Always discuss trial participation with your own doctor first.

Locations (33)

University Hospital MannheimMannheim, Baden-Wurttemberg, GermanyRecruiting
RHÖN-KLINIKUM Campus Bad NeustadtBad Neustadt an der Saale, Bavaria, GermanyActive Not Recruiting
Therapiezentrum BurgauBurgau, Bavaria, GermanyActive Not Recruiting
REGIOMED Klinikum CoburgCoburg, Bavaria, GermanyRecruiting
Universitätsklinikum ErlangenErlangen, Bavaria, GermanyRecruiting
Klinikum IngolstadtIngolstadt, Bavaria, GermanyRecruiting
RoMed KlinikumRosenheim, Bavaria, GermanyActive Not Recruiting
Cardiologicum HamburgHamburg, Free and Hanseatic City of Hamburg, GermanyRecruiting
Asklepios Klinik WandsbekHamburg, Free and Hanseatic City of Hamburg, GermanyRecruiting
Asklepios Klinik Nord HeidbergHamburg, Free and Hanseatic City of Hamburg, GermanyRecruiting
Asklepios Klinik AltonaHamburg, Free and Hanseatic City of Hamburg, GermanyRecruiting
Herz-Kreislauf-ZentrumRotenburg an der Fulda, Hesse, GermanyActive Not Recruiting

+ 21 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT04298723