Condition: Extranodal Natural Killer/T-Cell Lymphoma, Nasal Type · Classical Hodgkin Lymphoma · Sponsor: Baylor College of Medicine
This study involved patients that have a cancer called diffuse large B cell lymphoma (DLBCL), NK and T cell lymphomas (NK/TL) or classical Hodgkin lymphoma (cHL) (hereafter these 3 diseases will be referred to as lymphoma). Patients lymphoma has come back or not gone away after treatment. Because there is no standard treatment for the patients cancer at this time or because the currently used treatments do not work fully in all cases, the patients are being asked to volunteer in this research study. In this study the investigators want to test a type of T cell made from a normal donor. The T cells the investigators will use are called Epstein Barr virus (EBV) specific T cells (EBVSTs) and are cells that the investigators have trained in the laboratory to recognize a EBV which is the virus that causes mono or kissing disease. Some patients with lymphoma have EBV in their cancer cells. Researchers have given T cell lines from normal donor EBVSTs to lymphoma patients who have EBV in their lymphoma cells and have seen responses in about half the patients. The cells have have been generated and are frozen in a bank. The cells are called "allogeneic" (meaning the donor is not related to the patient). CD30.CAR in EBV-specific T cells (called allogeneic CD30.CAR-EBVST) from the blood of healthy donors. The investigators are giving the cells to patients with lymphoma cells that express CD30. If the lymphoma cells also express EBV there may be some benefit from targeting both proteins…
This description comes directly from the study's public registry record.
Carlos Ramos, MD · 832-824-4817 · caramos@bcm.edu
Vicky Torrano · (832) 824-7821 · vtorrano@bcm.edu-
Always discuss trial participation with your own doctor first.
| Houston Methodist Hospital | Houston, Texas, United States | Recruiting |
| Texas Children's Hospital | Houston, Texas, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT04288726