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Study identifier: NCT04282629 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Cerebral Hemodynamic Optimization by Milrinone to Prevent Delayed Cerebral Ischemia

Condition: Aneurysmal Subarachnoid Hemorrhage  ·  Sponsor: University Hospital, Toulouse

PhasePhase 2
Planned participants234
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The present study is a randomized, multi-center, double-blind, prospective study that tests the efficacy of intravenous milrinone to optimize cerebral hemodynamic and prevent delayed cerebral ischemia (DCI) during the high-risk period (day 4- day 14) in patients with severe subarachnoid hemorrhage due to intracranial aneurysm rupture (SAHa) (WFNS IV-V). The main objective is to evaluate, in comatose patients and / or sedated on D3 following a severe SAHa (WFNS IV -V), the effect of 10 days of milrinone versus placebo, in addition to the usual management, on the volume of DCI lesions measured on CT scan at 1 month.

This description comes directly from the study's public registry record.

Talk to the study team

Thomas Geeraerts, MD PhD  ·  056-177-2100  ·  geeraerts.t@chu-toulouse.fr

Nadera AINAOUI  ·  056-177-2498  ·  nadera.ainaoui@inserm.fr

Always discuss trial participation with your own doctor first.

Locations (5)

University Hospital BordeauxBordeaux, FranceActive Not Recruiting
CHUGAGrenoble, FranceActive Not Recruiting
University Hospital of La RéunionLa Réunion, FranceRecruiting
HCLLyon, FranceRecruiting
University Hospital of ToulouseToulouse, FranceRecruiting

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Source record: clinicaltrials.gov/study/NCT04282629