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Study identifier: NCT04282044 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Study of CRX100 as Monotherapy and in Combination With Pembrolizumab in Patients With Advanced Solid Malignancies

Condition: Solid Tumor, Adult · Triple Negative Breast Cancer · Colorectal Cancer  ·  Sponsor: BioEclipse Therapeutics

PhasePhase 1
Planned participants60
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This clinical study is an open-label, Phase 1, dose-escalation study to determine the safety, tolerability, and efficacy of the drug product produced by Administering CRX100 alone and in combination with Pembrolizumab in advanced solid malignancies. Patients will be screened and evaluated to determine whether or not they meet stated inclusion criteria. Enrolled subjects will undergo leukapheresis to enable the ex vivo generation of CRX100. Patients with non-small cell lung cancer (NSCLC), ovarian cancer, colorectal cancer, hepatocellular carcinoma (HCC), malignant melanoma (excluding uveal melanoma), gastric cancer, triple negative breast cancer, and osteosarcoma. The study will start with monotherapy dose escalation followed by combination cohorts.

This description comes directly from the study's public registry record.

Talk to the study team

Jennifer Lindal  ·  206-229-5827  ·  clinical@bioeclipse.com

Pamela Contag, PhD Chief Executive Officer  ·  info@bioeclipse.com

Always discuss trial participation with your own doctor first.

Locations (3)

HonorHealth Research InstituteScottsdale, Arizona, United StatesRecruiting
UC San Diego Moores Cancer CenterLa Jolla, California, United StatesRecruiting
Stanford UniversityStanford, California, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT04282044