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Study identifier: NCT04276870 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Orphan Indications for CD19 Redirected Autologous T Cells

Condition: Pediatric and Young Adult Patientswith Hypodiploid or t(17;19) B-ALL · Infants With Very High Risk KMT2A B-ALL · Patients With Central Nervous System Relapse Who Did Not Receive Cranial Radiation or Bone Marrow Transplantation  ·  Sponsor: Stephan Grupp MD PhD

PhasePhase 2
Planned participants133
Who can joinAll sexes, 0 Years to 29 Years
Healthy volunteersNo

About this study

This is an open-label, four-cohort, phase 2 study to determine the efficacy of CART19 in pediatric and young adult patientswith hypodiploid (Cohort A) or t(17;19) B-ALL (Cohort B), infants with very high risk KMT2A B-ALL (Cohort C), and in patients with central nervous system (CNS) relapse who did not receive cranial radiation (XRT) or bone marrow transplantation (BMT) (Cohort D).

This description comes directly from the study's public registry record.

Talk to the study team

CART Nurse Navigator  ·  445-942-5891  ·  CARTNurseNavigator@chop.edu

Melissa S Varghese, M.S.  ·  845-553-5358  ·  varghesem@chop.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Children's Hospital of PhiladelphiaPhiladelphia, Pennsylvania, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT04276870