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Study identifier: NCT04275726 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

LANDMARK Trial: a Randomised Controlled Trial of Myval THV

Condition: Aortic Valve Stenosis  ·  Sponsor: Meril Life Sciences Pvt. Ltd.

PhaseNA
Planned participants988
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The primary objective of this study (LANDMARK) is to compare the safety and effectiveness of the Myval THV Series with Contemporary Valves (Sapien THV Series and Evolut THV Series) in patients with severe symptomatic native aortic valve stenosis. This study will be done in total 768 subjects (384:384, Myval THV Series vs. Contemporary Valves) The randomisation will be carried out with an allocation ratio of 1:1 between Myval THV Series vs. Contemporary Valves (Sapien THV Series and Evolut THV Series)

This description comes directly from the study's public registry record.

Talk to the study team

Ashok Thakkar, PhD  ·  +91-9879443584  ·  ashok.thakkar@merillife.com

Always discuss trial participation with your own doctor first.

Locations (54)

Republican Scientific-Practical Centre "Cardiology"Minsk, BelarusNot Yet Recruiting
Hospital Dante PazanesseSão Paulo, BrazilRecruiting
Split Clinical Hospital CenterSplit, CroatiaRecruiting
University Hospital Dubrava Avenija Gojka Šuška 6Zagreb, CroatiaRecruiting
North Estonia Medical CenterTallinn, EstoniaRecruiting
Hôpital Henri MondorCréteil, FranceRecruiting
Lille UniversityLille, FranceRecruiting
Institut Cardiovascular Paris-SudMassy, FranceRecruiting
Arnault Tzanck InstituteNice, FranceRecruiting
Centre Hospitalier Universitaire De RennesRennes, FranceNot Yet Recruiting
Kerckhoff-KlinikForschungs GmbHBad Nauheim, Hesse, GermanyRecruiting
Leipzig Heart Institute GmbHLeipzig, Saxony, GermanyRecruiting

+ 42 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT04275726