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Study identifier: NCT04271956 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Efficacy and Safety of Zanubrutinib Plus Tislelizumab Treatment with or Without Sonrotoclax for Patients with Richter Transformation

Condition: Richter Transformation  ·  Sponsor: German CLL Study Group

PhasePhase 2
Planned participants83
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The aim of the CLL-RT1 trial is to evaluate the efficacy and safety of zanubrutinib (BGB-3111), a BTK inhibitor plus tislelizumab (BGB-A317), a PD1 inhibitor for treatment of patients with Richter Transformation

This description comes directly from the study's public registry record.

Talk to the study team

Barbara Eichhorst, Prof.  ·  +4922147888220  ·  barbara.eichhorst@uk-koeln.de

Othman Al-Sawaf, MD  ·  +4922147888220  ·  othman.al-sawaf@uk-koeln.de

Always discuss trial participation with your own doctor first.

Locations (11)

Allgemeines Krankenhaus der Stadt WienVienna, AustriaRecruiting
RigshospitaletCopenhagen, DenmarkRecruiting
Charité BerlinBerlin, State of Berlin, GermanyNot Yet Recruiting
Uniklinik KölnCologne, GermanyRecruiting
Universitätsklinikum Carl Gustav CarusDresden, GermanyRecruiting
Universitätsklinikum EssenEssen, GermanyRecruiting
Universitätsklinikum Schleswig-Holstein Campus KielKiel, GermanyRecruiting
H.O.T Praxis LandshutLandshut, GermanyRecruiting
Brüderkrankenhaus St. Josef PaderbornPaderborn, GermanyRecruiting
Universitätsmedizin RostockRostock, GermanyRecruiting
Universitätsklinik UlmUlm, GermanyRecruiting

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Source record: clinicaltrials.gov/study/NCT04271956