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Study identifier: NCT04271878 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Hypercapnia and Orthostatic Tolerance in Postural Orthostatic Tachycardia Syndrome

Condition: Postural Tachycardia Syndrome · Orthostatic Intolerance  ·  Sponsor: University of Calgary

PhaseNA
Planned participants26
Who can joinAll sexes, 18 Years to 60 Years
Healthy volunteersNo

About this study

The mechanism behind postural orthostatic tachycardia syndrome (POTS) involves many causes including a sympathetic nervous system problem. Blood gases, like carbon dioxide (CO2), have an important effect on sympathetic activation. The purpose of this research study is to determine if higher CO2 levels have any effect in lowering heart rate and reducing POTS symptoms when upright/standing. The investigators are also searching for the ideal CO2 concentration to achieve the most effective response

This description comes directly from the study's public registry record.

Talk to the study team

Shaun Ranada, BSc  ·  403-210-6152  ·  shaun.ranada@ucalgary.ca

Rasha Hamza, RN  ·  403-210-6152  ·  autonomic.research@ucalgary.ca

Always discuss trial participation with your own doctor first.

Locations (1)

University of CalgaryCalgary, Alberta, CanadaRecruiting

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Source record: clinicaltrials.gov/study/NCT04271878