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Study identifier: NCT04254419 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Phase 1 Study of Locoregional Injections of Ex Vivo Expanded Natural Killer Cells

Condition: High Grade Glioma  ·  Sponsor: Nationwide Children's Hospital

PhasePhase 1
Planned participants18
Who can joinAll sexes, 12 Months to 39 Years
Healthy volunteersNo

About this study

Each patient will receive up to 12 cycles of TGFβi NK cell infusions. Each cycle will be of 4 weeks duration. During the first 3 weeks, TGFβi NK cells will be infused once weekly. The 4th week will be a rest week. TGFβi NK cell infusions should be delivered at least 3 days apart (e.g., Friday of Week 1 and Monday of Week 2). Dose will be escalated in an inter-patient stepwise fashion consisting of 3 dose levels.

This description comes directly from the study's public registry record.

Talk to the study team

Clelie Peck  ·  614-722-5634  ·  Clelie.Peck@nationwidechildrens.org

Lauren Rayman  ·  614-722-3729  ·  lauren.rayman2@nationwidechildrens.org

Always discuss trial participation with your own doctor first.

Locations (1)

Nationwide Children's HospitalColumbus, Ohio, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT04254419