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Study identifier: NCT04248569 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

DNAJB1-PRKACA Fusion Kinase Peptide Vaccine Combined With Nivolumab and Ipilimumab for Patients With Fibrolamellar Hepatocellular Carcinoma

Condition: Fibrolamellar Hepatocellular Carcinoma (FLC)  ·  Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

PhasePhase 1
Planned participants56
Who can joinAll sexes, 12 Years to no upper limit
Healthy volunteersNo

About this study

The primary objective of the trial is the safety and tolerability of administering a vaccine targeting the DNAJB1-PRKACA fusion kinase, in combination with nivolumab and ipilimumab in patients with unresectable or metastatic FLC and with non-FLC solid tumors and to assess the T-cell response.

This description comes directly from the study's public registry record.

Talk to the study team

Colleen Apostol, RN  ·  410-614-3644  ·  GIClinicalTrials@jhmi.edu

Marina Baretti, MD  ·  410-614-1058  ·  mbarett1@jhu.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Sidney Kimmel Comprehensive Cancer CenterBaltimore, Maryland, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT04248569