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Study identifier: NCT04243720 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Immune Resistance Interrogation Study

Condition: Cancer · Solid Tumor · Metastatic Cancer  ·  Sponsor: University Health Network, Toronto

PhaseN/A
Planned participants100
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a prospective research study which will include patients who have progressed on immunotherapy as their most recent line of therapy. This study aims to characterize whether patients who fail to respond to immunotherapy versus patients who respond initially but after a period of time progress demonstrate different genomic, transcriptomic, epigenetic, immunophenotyping profiles. Patients will have a one-time fresh tumor biopsy. Serial blood samples (total amount of blood drawn may not exceed the lesser of 50 mL or 3 mL/kg in an 8 week period), archival tissue (if available) and one stool sample will be collected.

This description comes directly from the study's public registry record.

Talk to the study team

Celeste Yu  ·  416-946-4501  ·  celeste.yu@uhn.ca

Always discuss trial participation with your own doctor first.

Locations (1)

Princess Margaret Cancer CentreToronto, Ontario, CanadaRecruiting

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Source record: clinicaltrials.gov/study/NCT04243720