Condition: Congenital Heart Disease in Children · Neuroprotection · Sponsor: dr. M.J.N.L. Benders
Neurodevelopmental impairment due to delayed brain development and brain injury is a fundamental problem in children with critical congenital heart disease (CCHD). Significant longterm motor-, cognitive-, and behavioral problems are the result of early postnatally and perioperatively induced brain injury. Allopurinol, a xanthine oxidase inhibitor, prevents the formation of toxic free oxygen radicals, thereby limiting hypoxia-reperfusion damage. Both animal and neonatal studies suggest that administration of allopurinol reduces hypoxic-ischemic brain injury, is cardioprotective, and safe. This study aims to evaluate the efficacy and safety of allopurinol administered early postnatally and perioperatively in children with a CCHD requiring cardiac surgery with cardiopulmonary bypass.
This description comes directly from the study's public registry record.
Manon JNL Benders, Prof. MD PhD · 0031887554545 · m.benders@umcutrecht.nl
Maaike Nijman, MD · m.nijman@umcutrecht.nl
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| University Medical Center Groningen (UMCG) | Groningen, Netherlands | Recruiting |
| Radboud University Medical Center Nijmegen (Radboudumc) | Nijmegen, Netherlands | Active Not Recruiting |
| Erasmus Medical Center Rotterdam (Erasmus MC) | Rotterdam, Netherlands | Recruiting |
| University Medical Center Utrecht (UMC Utrecht) | Utrecht, Netherlands | Recruiting |
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Source record: clinicaltrials.gov/study/NCT04217421