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Study identifier: NCT04209504 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Evaluating Hemidiaphragmatic Paralysis With Prolonged Neural Blockade From an Interscalene Brachial Plexus Block

Condition: Shoulder Surgery · Shoulder Pain · Shoulder Injuries  ·  Sponsor: Duke University

PhaseN/A
Planned participants60
Who can joinAll sexes, 18 Years to 80 Years
Healthy volunteersNo

About this study

This prospective observational study aims to evaluate the incidence of hemidiaphragmatic paralysis in patients receiving interscalene brachial plexus nerve block with prolonged neural blockade. English speaking American Society of Anesthesiologists (ASA) 1-3 patients ages 18-80 receiving prolonged interscalene nerve block will be randomized into 3 groups: first group receiving a perineural catheter infusing 0.2% ropivacaine; the second group receiving a single shot injection of 10mL liposomal bupivacaine (Exparel; n=20) plus 5 mL 0.5% bupivacaine and the third receiving 20mL liposomal bupivacaine plus 5mL bupivacaine (to be determined by the attending anesthesiologist).Primary outcome will be incidence of hemidiaphragmatic paralysis postoperative day 1 as measured by point of care (POCUS) ultrasound.

This description comes directly from the study's public registry record.

Talk to the study team

WIlliam M Bullock, MD, PhD  ·  919-681-6437  ·  william.bullock@duke.edu

Amanda Kumar, MD  ·  919-681-6437  ·  amanda.kumar@duke.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Duke University HospitalDurham, North Carolina, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT04209504