Condition: Metastatic Small Intestinal Adenocarcinoma · Stage III Small Intestinal Adenocarcinoma AJCC v8 · Stage IIIA Small Intestinal Adenocarcinoma AJCC v8 · Sponsor: SWOG Cancer Research Network
This phase II trial studies how well ramucirumab and paclitaxel or the FOLFIRI regimen (leucovorin calcium, fluorouracil, and irinotecan hydrochloride) work in treating patients with small bowel cancers that have spread extensively to other anatomic sites (advanced) or are no longer responding to treatment (refractory). Ramucirumab is a monoclonal antibody that attaches to and inhibits a molecule called VEGFR-2. This may restrain new blood vessel formation therefore reducing nutrient supply to tumor which may interfere with tumor cell growth and expansion. Drugs used in chemotherapy, such as paclitaxel, leucovorin calcium, fluorouracil, and irinotecan hydrochloride work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving Ramucirumab plus paclitaxel or FOLFIRI, may be helpful in treating advanced or refractory small bowel cancers and may help patients live longer.
This description comes directly from the study's public registry record.
Christy Klepetko · 210/614-8808 · cklepetko@swog.org
Dana Sparks · 210/614-8808 · dsparks@swog.org
Always discuss trial participation with your own doctor first.
| Anchorage Associates in Radiation Medicine | Anchorage, Alaska, United States | Recruiting |
| Anchorage Radiation Therapy Center | Anchorage, Alaska, United States | Suspended |
| Alaska Breast Care and Surgery LLC | Anchorage, Alaska, United States | Recruiting |
| Alaska Oncology and Hematology LLC | Anchorage, Alaska, United States | Recruiting |
| Alaska Women's Cancer Care | Anchorage, Alaska, United States | Recruiting |
| Anchorage Oncology Centre | Anchorage, Alaska, United States | Suspended |
| Katmai Oncology Group | Anchorage, Alaska, United States | Recruiting |
| Providence Alaska Medical Center | Anchorage, Alaska, United States | Recruiting |
| Kingman Regional Medical Center | Kingman, Arizona, United States | Recruiting |
| Cancer Center at Saint Joseph's | Phoenix, Arizona, United States | Active Not Recruiting |
| Mercy Hospital Fort Smith | Fort Smith, Arkansas, United States | Recruiting |
| CHI Saint Vincent Cancer Center Hot Springs | Hot Springs, Arkansas, United States | Suspended |
+ 524 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT04205968