Condition: HbS Disease · Hemoglobin S Disease · Sickle Cell Anemia · Sponsor: University of Regensburg
HSCT is currently the only curative option for SCD but less than 20% of SCD patients have a MD donor available. So far, all curative approaches beyond a MSD HSCT at young age are non-satisfactory. With the lack of a suitable donor for the vast majority of patients, the major question of this trial is, if a haploidentical αß/CD19+ T-cell depleted HSCT can be a valid alternative to a MSD HSCT. The main challenge in non-malignant diseases is to offer a safe and GvHD-free HSCT without rejection.
This description comes directly from the study's public registry record.
Selim Corbacioglu, MD · +49 (0)941 944-2101 · Haplo.SCD@ukr.de
Katharina Kleinschmidt, MD · +49 (0)941 944-2101 · Haplo.SCD@ukr.de
Always discuss trial participation with your own doctor first.
| St. Anna Kinderspital | Vienna, Austria | Not Yet Recruiting |
| University Hospital Aachen, Children's Hospital | Aachen, Germany | Not Yet Recruiting |
| Charité University medicine, Clinic for Hematology, Oncology | Berlin, Germany | Not Yet Recruiting |
| University Hospital Duesseldorf, Clinic for Pediatric Oncology, - Hemtaology and Clinical Immunology | Düsseldorf, Germany | Not Yet Recruiting |
| University Hospital of Frankfurt, Clinic for Paediatrics and Adolescent Medicine | Frankfurt, Germany | Not Yet Recruiting |
| University Hospital Heidelberg, Department of Pediatric Hematology, Oncology and Immunology | Heidelberg, Germany | Recruiting |
| University Hospital Regensburg, Dept. of Ped. Hematology, Oncology and Stem Cell Transplantation | Regensburg, Germany | Recruiting |
| University Children's Hospital Tübingen | Tübingen, Germany | Recruiting |
| University Children's Hospital Würzburg | Würzburg, Germany | Recruiting |
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Source record: clinicaltrials.gov/study/NCT04201210