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Study identifier: NCT04198766 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Study of INBRX-106 and INBRX-106 in Combination With Pembrolizumab (Keytruda®) in Subjects With Locally Advanced or Metastatic Solid Tumors (Hexavalent OX40 Agonist)

Condition: Solid Tumor · Non-Small Cell Lung Cancer · Head and Neck Cancer  ·  Sponsor: Inhibrx Biosciences, Inc

PhasePhase 1/Phase 2
Planned participants340
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a Phase 1/2, open-label, non-randomized, 4-part trial to determine the safety profile and identify the maximum tolerated dose (MTD) and/or recommended Phase 2 dose (RP2D) of INBRX 106 administered as a single agent or in combination with the anti-PD-1 checkpoint inhibitor (CPI) pembrolizumab (Keytruda®). KEYTRUDA is a registered trademark of Merck Sharp \& Dohme LLC, a subsidiary of Merck \& Co., Inc., Rahway, NJ, USA.

This description comes directly from the study's public registry record.

Talk to the study team

Study Director - Inhibrx Biosciences, Inc  ·  858-500-7833  ·  clinicaltrials@inhibrx.com

Always discuss trial participation with your own doctor first.

Locations (42)

City of HopeDuarte, California, United StatesRecruiting
Los Angeles Cancer NetworkGlendale, California, United StatesRecruiting
California Research InstituteLos Angeles, California, United StatesRecruiting
Valkyrie Clinical TrialsLos Angeles, California, United StatesRecruiting
Valkyrie Clinical TrialsMurrieta, California, United StatesRecruiting
Providence Medical FoundationSanta Rosa, California, United StatesRecruiting
Clermont Oncology CenterClermont, Florida, United StatesRecruiting
Mid Florida Hematology and Oncology CenterOrange City, Florida, United StatesRecruiting
Winship Cancer Institute - Emory UniversityAtlanta, Georgia, United StatesRecruiting
The University of Chicago Medical CenterChicago, Illinois, United StatesActive Not Recruiting
University of IowaIowa City, Iowa, United StatesActive Not Recruiting
Norton Cancer InstituteLouisville, Kentucky, United StatesRecruiting

+ 30 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT04198766