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Study identifier: NCT04194619 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Pregnancy in Women With Rare Multisystemic Vascular Diseases: COGRare5 Study

Condition: Vascular Anomaly · Osler Rendu Disease · Marfan Syndrome or Related  ·  Sponsor: Hospices Civils de Lyon

PhaseN/A
Planned participants400
Who can joinFemale, 18 Years to 45 Years
Healthy volunteersNo

About this study

There are no prospective studies of pregnancies for the diseases studied here in (Heredity Hemorrhagic Telangiectasia, Marfan syndrome or related, primary lower limb lymphedema, superficial arteriovenous malformations, and cerebro-spinal arteriovenous malformations) although complications of these can present life-threatening health problems for the mother and her baby. The purpose of this National prospective study is to obtain greater insight into obstetrical complications associated with rare maternal vascular genetic disorders in order to improve prevention and to reduce risk of death. In this context, experts and patient associations consider that there is a need to make real progress in the formulation of recommendations based on scientific data.

This description comes directly from the study's public registry record.

Talk to the study team

Sophie DUPUIS-GIROD, MD  ·  04 27 85 65 25  ·  sophie.dupuis-girod@chu-lyon.fr

Amal AYADI ROBERT  ·  04 27 85 66 03  ·  amal.ayadi@chu-lyon.fr

Always discuss trial participation with your own doctor first.

Locations (36)

Service de Médecine Interne et Maladies Vasculaires + Service Neuropédiatrie et neurochirurgie de l'enfant - CHU AngersAngers, FranceRecruiting
Service de Médecine interne et immunologie clinique + Service de Médecine Vasculaire - Hôpital Saint André, CHU de BordeauxBordeaux, FranceWithdrawn
Service Pneumologie et Oncologie Thoracique - AP-HP Hôpital Ambroise ParéBoulogne-Billancourt, FranceRecruiting
Centre de Référence pour la maladie de Rendu-Osler - Service Génétique Clinique - Hôpital Femme-Mère-Enfant - Hospices Civils de LyonBron, FranceRecruiting
Service d'imagerie médicale - Neuroradiologie interventionnelle - Hôpital Neurologique P. Wertheimer - HCLBron, FranceWithdrawn
Service d'Imagerie Pédiatrique et Fœtale et Consultation Pluridisciplinaire des Angiomes - Hôpital Femme-Mère-Enfant - HCLBron, FranceRecruiting
Service de Génétique, Hôpital Femme-Mère-EnfantBron, FranceRecruiting
Service de Médecine Vasculaire - Hôpital de la Côte de NacreCaen, FranceRecruiting
Service Médecine Interne Estaing CHU de Clermont-Ferrand - Hôpital d'EstaingClermont-Ferrand, FranceRecruiting
CHU Dijon Bourgogne - Hôpital François MitterrandDijon, FranceRecruiting
Service de Médecine vasculaire et HTA - Hôpital Albert Calmette, CHRU de LilleLille, FranceRecruiting
Service Médecine interne - CHRU de Lille - Hôpital Claude HuriezLille, FranceRecruiting

+ 24 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT04194619