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Study identifier: NCT04192773 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

An fMRI Investigation of the Effects of IV Lidocaine on Tinnitus

Condition: Tinnitus  ·  Sponsor: D. Bradley Welling, MD, PhD

PhaseEARLY_Phase 1
Planned participants40
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersYes

About this study

This is an exploratory pilot open-label study to identify the signal changes on fMRI of patients with tinnitus and with temporary suppression of the tinnitus with IV lidocaine. Patients will include those with hearing loss (both unilateral and bilateral) and tinnitus, subjects with normal hearing and tinnitus, and control subjects with normal hearing and no tinnitus. Eligible subjects will have functional and subjective data collected at baseline, receive an IV lidocaine infusion, and have functional and subjective data collected post-infusion for comparison and identification of involved neural networks.

This description comes directly from the study's public registry record.

Talk to the study team

D. Bradley Welling, MD, PhD  ·  617-573-6016  ·  simonyan_lab@meei.harvard.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Massachusetts Eye and Ear InfirmaryBoston, Massachusetts, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT04192773