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Study identifier: NCT04191681 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Safety and Efficacy of ARNI After LVAD ImplanT (SEAL-IT) Study

Condition: Stage D Heart Failure  ·  Sponsor: The Cleveland Clinic

PhasePhase 4
Planned participants50
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of the study is to evaluate how well tolerated and effective an angiotensin receptor-neprilysin inhibitor (sacubitril-valsartan) is in patients with contemporary durable continuous flow left ventricular assist device (CF-LVAD) implantation compared to usual care oral vasodilator therapy.

This description comes directly from the study's public registry record.

Talk to the study team

Jerry D Estep, MD  ·  216-444-7646  ·  estepj@ccf.org

Always discuss trial participation with your own doctor first.

Locations (1)

Cleveland ClinicCleveland, Ohio, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT04191681