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Study identifier: NCT04176198 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Study of Oral Nuvisertib (TP-3654) in Patients With Myelofibrosis

Condition: Myelofibrosis  ·  Sponsor: Sumitomo Pharma America, Inc.

PhasePhase 1/Phase 2
Planned participants240
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study is a Phase 1/2, multicenter, dose-escalation, open-label trial to assess safety, tolerability, pharmacokinetics and pharmacodynamics of nuvisertib (TP-3654) in patients with intermediate or high-risk primary or secondary MF.

This description comes directly from the study's public registry record.

Talk to the study team

Reyna Bishop  ·  617-674-6800  ·  reyna.bishop@us.sumitomo-pharma.com

Jordan Simpson  ·  jordan.simpson@us.sumitomo-pharma.com

Always discuss trial participation with your own doctor first.

Locations (84)

University of AlabamaBirmingham, Alabama, United StatesRecruiting
The University of Arizona Cancer CenterTucson, Arizona, United StatesRecruiting
City of HopeDuarte, California, United StatesRecruiting
University of Southern CaliforniaLos Angeles, California, United StatesRecruiting
Hoag Family Cancer InstituteNewport Beach, California, United StatesRecruiting
Blood Cancer CenterDenver, Colorado, United StatesRecruiting
Yale School of MedicineNew Haven, Connecticut, United StatesRecruiting
University of Florida Health Shands Cancer HospitalGainesville, Florida, United StatesCompleted
University of MiamiMiami, Florida, United StatesRecruiting
Baptist Health - Miami Cancer InstituteMiami, Florida, United StatesRecruiting
Emory UniversityAtlanta, Georgia, United StatesRecruiting
University of ChicagoChicago, Illinois, United StatesRecruiting

+ 72 more locations — full list on the registry record.

Follow this study

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Source record: clinicaltrials.gov/study/NCT04176198