Condition: Age-related Cognitive Decline · Mild Cognitive Impairment · Dementia · Sponsor: University of Alabama at Birmingham
Older adults at risk for dementia show a variety of cognitive deficits, which can be ameliorated by different cognitive training (CT) exercises. The best combination of CT exercises is unknown. The aim is to discover the most efficacious combination of CT exercises as compared to cognitive stimulation (which will serve as a stringent, active control) to modify the functional trajectories of older adults' with MCI, who are at high risk for dementia. The primary objective of the U01 phase was to design and pilot-test an adaptive, randomized clinical trial (RCT) of cognitive training (CT) combinations aimed to enhance performance of instrumental activities of daily living (IADL) among persons with mild cognitive impairment (MCI). In the R01 phase, the objective is to identify the best combination of CT exercises to delay dementia onset among persons with MCI. The longitudinal endpoint goal is reducing incident dementia. The primary aim of the study is to determine which CT combination has the best probability to delay dementia by producing the largest IADL improvements. The study further aims to explore neuroimaging and novel blood-based biomarkers.
This description comes directly from the study's public registry record.
Jerri Edwards, PhD · 864-916-6220 · activemindcoordinator@gmail.com
Jade Sutfin · 864-916-6220 · activemindcoordinator@gmail.com
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| University of California San Francisco | San Francisco, California, United States | Recruiting |
| University of Florida | Gainesville, Florida, United States | Recruiting |
| Active Mind Study | Tampa, Florida, United States | Recruiting |
| University of Minnesota | Minneapolis, Minnesota, United States | Active Not Recruiting |
| Clemson University | Greenville, South Carolina, United States | Recruiting |
| Clemson University | Seneca, South Carolina, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT04171323