Condition: Metastases to Bone · Metastatic Breast Cancer · Metastatic NSCLC · Sponsor: Hospices Civils de Lyon
Osteolytic bone metastases and myeloma bone lesions are responsible of long bone and vertebral fractures leading to restricted mobility, surgery and medullar compression that severely alter quality of life and that have a huge medico-economic impact. It has been estimated that 50% of the patients with bone metastasis will encounter bone complications. In the recent years, Bone Oncology Multidisciplinary Meetings have been developed to optimize bone metastases management for each patient in harmony with oncology program. The assessment of the fracture risk of bone metastasis remains fairly empirical and is based on simple radiography. The Mirel's score for long bones is focused on the extent of cortical defect caused by bone metastasis to identify high-risk patients at risk of fracture during surgery. It is old, little used in routine and lacks sensitivity and specificity. The SINS (Spinal Instability Neoplastic Score) score is the reference for vertebrae. Today, most patients with fracture-risk bone metastasis benefit from a lesion-centered CT scan to better characterize its extent and position but the interpretation remains qualitative. Metastases are considered as an air cavity and the mechanical properties of the tumor are not evaluated. However, many other parameters from the CTscan are available such as cortical or trabecular compartment densitometry, cortical thickness, tumor volume, and position of lysis in the bone. Based on experience acquired by the service in the…
This description comes directly from the study's public registry record.
Cyrille CONFAVREUX, PR · 4.78.86.12.31 · cyrille.confavreux@chu-lyon.fr
Sara CALATTINI · 4.78.86.37.79 · sara.calattini@chu-lyon.fr
Always discuss trial participation with your own doctor first.
| Service de rhumatologie, CHU d'Angers | Angers, France | Recruiting |
| Ch Annecy Genevois | Annecy, France | Recruiting |
| Service de radiothérapie, Institut Jean-Perrin | Clermont-Ferrand, France | Recruiting |
| Service de rhumatologie, CH Annemasse | Contamine-sur-Arve, France | Recruiting |
| Service d'onco-rhumatologie, Centre Oscar Lombret | Lille, France | Recruiting |
| Service de Radiothérapie, Centre Léon Bérard, 28 Prom. Léa et Napoléon Bullukian | Lyon, France | Recruiting |
| Service d'oncologie médicale, Institut Curie, 26 rue d'Ulm | Paris, France | Recruiting |
| Service de Radiologie, Hôpital Cochin, Assistance Publique - Hôpitaux de Paris | Paris, France | Recruiting |
| Service de Rhumatologie, Hospices Civils de Lyon, Groupement Hospitalier Lyon Sud | Pierre-Bénite, France | Recruiting |
| Service de rhumatologie, CHU de Poitiers | Poitiers, France | Recruiting |
| Service de rhumatologie, CHU de Saint Etienne | Saint-Priest-en-Jarez, France | Recruiting |
| Institut de Cancérologie de Lorraine | Vandœuvre-lès-Nancy, France | Recruiting |
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Source record: clinicaltrials.gov/study/NCT04170634