Condition: Multiple System Atrophy · Sponsor: Ionis Pharmaceuticals, Inc.
The primary objectives are to evaluate the safety and tolerability of multiple doses of ION464 administered via intrathecal (IT) injection (Part 1) and to evaluate the long-term safety and tolerability of ION464 (Part 2) in participants with multiple system atrophy (MSA). The secondary objectives are to evaluate the pharmacodynamic (PD) effect of ION464 on the level of a potential biomarker of target engagement (Parts 1 and 2) and to evaluate the pharmacokinetic (PK) profile of ION464 in serum (Part 1).
This description comes directly from the study's public registry record.
Ionis Pharmaceuticals, Inc. · (844) 748-5844 · IonisHORIZONStudy@clinicaltrialmedia.com
Always discuss trial participation with your own doctor first.
| Medizinische Universität Innsbruck | Innsbruck, Austria | Recruiting |
| CHU de Lyon - Hospices Civils de Lyon-H6pital Pierre Wertheimer, Neurologique HCL | Lyon, France | Recruiting |
| Groupe Hospitalier Pitie-Salpetriere | Paris, France | Recruiting |
| Hopital Purpan | Toulouse, France | Recruiting |
| Universitaetsklinikum Ulm | Ulm, Baden-Wurttemberg, Germany | Recruiting |
| Universitaetsklinikum Duesseldorf AoeR | Düsseldorf, Germany | Recruiting |
| University Medical Center Göttingen, Clinic for Neurology | Göttingen, Germany | Recruiting |
| Medizinische Hochschule Hannover (MHH) | Hanover, Germany | Completed |
| University Hospital Marburg | Marburg, Germany | Recruiting |
| Klinikum der Universtiatet Muenchen -Campus Grosshadern | München, Germany | Recruiting |
| Hospital Beatriz Ângelo | Loures, Portugal | Recruiting |
| Institute of Neurology & The National Hospital for Neurology and Neurosurgery | London, England, United Kingdom | Recruiting |
+ 3 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT04165486