Condition: Down Syndrome · Alzheimer Disease · Dementia · Sponsor: University of Southern California
The purpose of the Trial-Ready Cohort - Down Syndrome (TRC-DS) is to enroll 120 healthy adults with Down syndrome (DS), between the ages of 25-55, into a trial ready cohort (TRC), and up to 550 participants in total including co-enrolled in the Alzheimer Biomarkers Consortium - Down Syndrome (ABC-DS) study. Participants enrolled in the TRC-DS will undergo longitudinal cognitive and clinical assessment, genetic and biomarker testing, as well as imaging and biospecimen collection. Using these outcome measures, researchers will analyze the relationships between cognitive measures and biomarkers of Alzheimer's disease (AD) to identify endpoints for AD clinical trials in DS that best reflect disease progression. To learn more about the study and participating sites, visit our study website at: https://www.trcds.org/. TRC-DS is collaborating with the Alzheimer's Disease Biomarker Consortium-Down Syndrome (ABC-DS) to allow study participants to be concurrently enrolled in both ABC-DS and TRC-DS, referred to as "co-enrollment". ABC-DS is a longitudinal, observational research study that is overseen at University of Pittsburgh Coordinating Center. ABC-DS participants who express interest in potentially joining a clinical trial in the future and who meet TRC-DS eligibility criteria, may choose to co-enroll in TRC-DS at an ABC-DS Site. Co-enrolled participants will adhere to the ABC-DS protocol and schedule of activities, but agree to share their data with the TRC-DS team and to recei…
This description comes directly from the study's public registry record.
ATRI Recruitment Team · 213-821-0569 · DS-participate@usc.edu
Always discuss trial participation with your own doctor first.
| Barrow Neurological Institute | Phoenix, Arizona, United States | Recruiting |
| University of California, Irvine School of Medicine, Co-Enrolling through ABC-DS Only | Orange, California, United States | Recruiting |
| Linda Crnic Institute for Down Syndrome, University of Colorado | Aurora, Colorado, United States | Recruiting |
| Advocate Medical Group Adult Down Syndrome Center | Park Ridge, Illinois, United States | Not Yet Recruiting |
| Indiana University | Indianapolis, Indiana, United States | Recruiting |
| University of Kansas Medical Center | Kansas City, Kansas, United States | Recruiting |
| University of Kentucky, Co-Enrolling through ABC-DS Only | Lexington, Kentucky, United States | Recruiting |
| Massachusetts General Hospital, Co-Enrolling through ABC-DS Only | Boston, Massachusetts, United States | Recruiting |
| Washington University, St. Louis | St Louis, Missouri, United States | Recruiting |
| Cleveland Clinic, Lou Ruvo Center for Brain Health, Las Vegas | Las Vegas, Nevada, United States | Not Yet Recruiting |
| New York State Institute for Basic Research in Developmental Disabilities (SIBRDD), Co-Enrolling through ABC-DS Only | Staten Island, New York, United States | Recruiting |
| Case Western Reserve University | Beachwood, Ohio, United States | Recruiting |
+ 10 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT04165109